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Although the gene is the same in both sexes, it is processed differently in females. Contact us to opt out anytime. The male mosquitoes were unaffected by the edit. Female mosquitoes who only had one copy of doublesex disrupted were also fine, but insects with both copies of their gene broken displayed a slew of anomalies and intersex features, including underdeveloped reproductive organs and incorrectly formed male genitalia.


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The proboscises of these mutant mosquitoes were also malformed, rendering them unable to bite and sap blood. The group tested their gene drive in a population of caged mosquitoes, starting with normal female mosquitoes, normal male mosquitoes, and male mosquitoes that carried a single copy of the doublesex -disrupting CRISPR gene drive.

In one run of the experiment, the gene drive had spread to every single mosquito by only the seventh generation. By the eighth generation, all mosquitoes carried the gene drive and mutant doublesex gene, meaning no eggs were laid, and the entire population died. In another run of the experiment, the drive was spread to all mosquitoes in just 11 generations. If doublesex can mutate in a way that avoids being targeted by CRISPR, but still leaves the mosquitoes fertile, the gene drive would fail.

De-extinction

Department of Defense. The next step, now underway, is to test the gene drive in a larger population of mosquitoes caged under conditions that mimic the tropical environment favored by the insects in Africa. The power is now in your nitrile gloved hands Sign up for a free account to increase your articles.

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CRISPR gene editing drives caged mosquitoes to extinction

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Renew your membership, and continue to enjoy these benefits. Not Now. Grab your lab coat. Let's get started Welcome! It seems this is your first time logging in online. For a while , the banana companies carved new plantations from untouched rainforests. But this act of environmental vandalism only postponed the inevitable. Soon these areas, too, became contaminated and cultivation became unsustainable.


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Cavendish bananas were soon filling plantations, and it is now the banana we most commonly purchase. The Panama disease epidemic was stopped for some time, but now there is a new strain of the disease, and the Cavendish is no longer resistant. It is threatening thousands of hectares of Cavendish plantations as well as businesses and livelihoods. To get an idea of how influential the banana is on economies and daily lives, just look at the numbers :.

Fortunately, scientists and researchers are racing to find a solution to save the banana, and biology-driven innovations like gene editing may be the answer. Today, scientists are working to turn on the gene that would enable the Cavendish banana to be resistant against the new strain of Panama disease.

More from journalist Stuart Thompson:. However, genetic modification offers other ways to move properties between plants and other organisms. In principle this could offer a solution and there are already some promising results. Researchers in Australia have found that adding two different genes to the genetic code of Cavendish bananas protects the plants from TR4. Prominent Australian researchers have floated efforts to resurrect the species over the past two decades, as genetic engineering technology has steadily improved.

The most famous example came in , when paleontologist Michael Archer took over as director of the Australian Museum, Australia's oldest museum and a highly respected scientific institution. The idea immediately had its detractors. One of Archer's contemporaries, Janette Norman of Museum Victoria, called it "impossible" and a "fantasy," describing it as a "waste of time and research dollars. The project failed and was canned in Fourteen years ago, it was impossible. It was fantasy. And it was well before a team of researchers from Melbourne University, led by Andrew Pask, plucked the DNA from thylacine pups preserved in jars of alcohol and reconstructed the animal's entire genome in Tasmania is wild, green and sparsely populated.

Pask, like many Australians, is fascinated by the thylacine. For him, the fascination is part childlike wonder and part scientific interest. The thylacine was a truly unique modern-day marsupial. You've got bears and lions and tigers and killer whales. There are so many different examples of those animals that sit right at the top of the food chain," he explains. Apex predators are key elements in an ecosystem.

They're the bricks at the top of the imaginary pyramid, but their overall effects on the ecosystem touch all the other species in the structure. What would happen if the thylacine was reintroduced to the food chain? When wolves were reintroduced to Yellowstone Park in , that ecosystem underwent sweeping changes. The park's biodiversity flourished as beavers returned to the region for the first time in decades. Changes to the landscape, due to increased predation on elk, gave native flora a chance to bounce back. But even with a blueprint, the right habitat and good reason, there's still a lot of work to do before you get a living, breathing thylacine.

It's far further from resurrection than the mammoth or the passenger pigeon, because it lacks one characteristic defining both those projects: There's no obvious modern-day equivalent species to build a new thylacine from. The thylacine was a carnivore. It may not be a great starting point, but Pask and his team are sequencing the numbat's genome to see how similar the species are.

With CRISPR, the huge amount of changes necessary to transform a numbat to a thylacine still falls within the realm of possibility -- though not in the immediate future. While Pask says we have a "social obligation" to bring the thylacine back, he acknowledges the goal of his project is not de-extinction. Outside of asteroids, climate change and humongous volcanic eruptions, humans are one of the Earth's best exterminators. Conservationists such as Parrott operate on the opposite end of the spectrum from de-extinction researchers. They're focusing on the species alive today, threatened by habitat loss, disease, poaching and invasive species.

To preserve the natural world, these scientists have long relied on breeding programs and reintroduction of species into protected areas. Rebecca Johnson, leader of the Australian Museum Research Institute, is using the power of the genetic code to protect vulnerable species, such as the koala, from extinction. Habitat loss and disease are driving koala numbers down, but examining its genes could open up new avenues for its salvation. Johnson, and an international collaboration of scientists, published the koala genome in , providing a full map of the tree-climbing marsupial's DNA.

They criss-crossed the map like intrepid explorers searching for land, finding genes that defend against chlamydia, one of the koala's biggest threats, and lactation proteins that protect the young.

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Those insights can be used to inform future conservation efforts. It's obvious Johnson understands the attraction and benefits of de-extinction, but she doesn't believe we're quite ready for it.

Thinking nothing’s wrong

Using CRISPR for conservation "seems like a clean 'fix,'" she says, but the "long-term ramifications need to be taken into account, modeled and thoroughly tested. There is, however, one aspect of de-extinction research that may contribute to today's conservation efforts: engineering diversity. If you go smaller, to the level of the gene, then extinction has been absolutely devastating on this planet," says Novak, the biologist working on bringing back the passenger pigeon. There is an invisible crisis underlying the dramatic disappearance of species.

It's the loss of genetic diversity. The more genetically diverse a species, the more readily it can adapt to changing circumstances.


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  8. A more diverse species will be less susceptible to infectious diseases or the effects of climate change and might be able to survive an event that would otherwise render it extinct. It's in this space where de-extinction and conservation overlap. Koalas are an example of a species with low diversity. The lazy marsupial isn't exactly the most locomotive creature, and populations are separated by vast distances. Over time this results in a smaller and smaller gene pool due to inbreeding.

    Using CRISPR , scientists could bypass the genetic lottery of inheritance to add diversity back into the koala's gene pool. That gives conservationists a huge advantage. Anywhere in the world, at any point in time," says George Church, the mammoth resurrection scientist.

    The power is now in your (nitrile gloved) hands

    Conservationists could shift genes between populations of koalas from different locations and even different periods in history. If they find the koala's genetic diversity has fallen away, she thinks engineering diversity may be beneficial -- with one big caveat. In an extensive review on de-extinction published in the journal Genes , Novak suggests biotechnology has changed the very idea of extinction. After all, if we have the genetic code of a species and we can implant that code into a cell, is the species really extinct? It lives on, not in the physical form we're used to, but in the strands of DNA locked inside a cell.

    In the future, we may have the technology and know-how to turn that DNA into a full-grown animal.

    New koala gene map could help prevent extinction

    At the very least, researchers will be able to write genes from the distant past into the present. De-extinction could defeat death itself. And yet, if we take a look at the future of Earth, death seems painfully unavoidable for a startling amount of the planet's life.